In an ex vivo study, layering tazarotene with another active agent reduced tazarotene penetration into the epidermis and dermis1
At hour 24, the percent of applied dose of tazarotene was 400% more when tazarotene was applied alone vs when layered with Ultravate cream
Between hours 18 and 24, the percent of applied dose of tazarotene continued to increase with monotherapy while the layered combination of halobetasol cream and tazarotene remained stagnant
In a clinical study, psoriasis patients were more adherent with a once-daily administration of psoriasis medication (82%) than they were with twice-daily administration (44%)(P<0.001)2