A woman in a magenta shirt squeezes a small amount of DUOBRII Lotion onto her finger. Hal and Taz stand back-to-back in front of her hands.

How DUOBRII Lotion Works

Two well-known ingredients. One unique lotion.

Hal and Taz work together in a single,
first-of-its-kind topical treatment for plaque psoriasis

Meet HALthe Corticosteroid(halobetasol propionate)
character

Hal has powerful antiinflammatory abilities and reduces the burning and irritation associated with vitamin A derivatives. He works with Taz to clear plaques from your skin.

  • Across two clinical trials, the most common adverse events that patients experienced with DUOBRII Lotion were irritation (7%), application site pain (3%), skin thinning (2%), and excoriation (2%)
 
Meet TAZthe Retinoid(tazarotene)
character

Taz has been shown to reduce skin thinning associated with corticosteroids, with well-established tolerability in psoriasis when partnered with a corticosteroid. He extends the clearing process even after stopping treatment.

  • Across two clinical trials, 2% of patients using DUOBRII Lotion experienced skin thinning

Learn how Hal and Taz fight plaque psoriasis from the outside in

The strong antiinflammatory agent (halobetasol propionate) works to clear plaques, while the vitamin A derivative (tazarotene) helps extend the clearing process.

Newly diagnosed?

Learn more about plaque psoriasis

Results with DUOBRII Lotion

Hal and Taz walk side-by-side in the direction of the right of the page. Hal is holding a day-by-day calendar, with its pages falling off behind them as they walk. Hal and Taz walk side-by-side in the direction of the right of the page. Hal is holding a day-by-day calendar, with its pages falling off behind them as they walk.

Use DUOBRII Lotion once a day, only until your psoriasis is under control

All other potent-to-superpotent steroids have time limits on use.

Talk to your doctor if you experience skin thinning, stretch marks, spider veins or inflamed hair follicles.

Take control of your psoriasis with a treatment that keeps working after you stop using it

Clearance in as little as 2 weeks

In clinical studies, almost 10% of patients had
“clear” or “almost clear” skin at 2 weeks

Over 40% of patients had "clear" or "almost clear" skin at 8 weeks across 2 clinical trials
Continued clearance 1 month after DUOBRII Lotion

Across both trials, 33% of patients still had “clear” or “almost clear” skin 4 weeks post treatment

Long lasting results

19% of patients were still "clear" or "almost clear" 3 months after stopping treatment and some patients (7%) did not require any re-treatment during the length of a one year safety study

With DUOBRII Lotion, less than 2% of patients experienced skin thinning

The most common side effects that patients experienced with DUOBRII Lotion were skin irritation (7%), application site pain (3%), skin thinning (2%), and excoriation (2%)

Clear = no evidence of scaling, redness, or plaque elevation above normal skin level. Almost clear = some plaques with fine scales, faint pink/light redness on most plaques, slight or barely noticeable elevation of plaques above normal skin level.

DUOBRII Lotion Benefits

A once-daily lotion that:

Water droplet enclosed in a lime green circle.

Helps skin feel moisturized by reducing water loss

A white swatch of silk enclosed in a lime green circle.

Doesn't leave a greasy residue

A white feather enclosed in a lime green circle.

Goes on easily and feels light on the skin

Supported by a patient survey to assess moisturization/feel of the DUOBRII Lotion vehicle (N=15).

How to Apply DUOBRII Lotion

DUOBRII Lotion fits into your daily routine

Once a day:

1
Apply a thin layer to the affected area
2
Rub in gently
 

NOTE : If you have to be in the sun, always use sunscreen and wear protective clothing over treated areas. Avoid exposure to sunlamps while using DUOBRII Lotion. Visit the FAQ section for other important information regarding DUOBRII Lotion.

More detailed instructions and tips are available in this helpful guide to using DUOBRII Lotion

Finding a doctor
near you

Whether you have been diagnosed with plaque psoriasis or not, it's important to find a dermatologist you can talk to about your concerns and possible treatments. Use this tool to find a dermatologist in your area.

Discussing your condition
with your doctor

Having productive conversations with your doctor is an important part of getting the most out of treatment, and being prepared for each appointment will help. Whether you have been prescribed DUOBRII Lotion or not, this Doctor Discussion Guide will help you get started.

Up next…

Learn from others living with psoriasis

See More

What is DUOBRII® Lotion?

Important Safety Information

DUOBRII (halobetasol propionate and tazarotene) Lotion, 0.01%/0.045%, is a prescription medicine used on the skin (topical) to treat adults with plaque psoriasis. It is not known if DUOBRII Lotion is safe and effective in children.

Important Safety Information

  • DUOBRII Lotion is for use on the skin only; do not use it in your mouth, eyes, or vagina.
  • DUOBRII Lotion is for use on the skin only; do not use it in your mouth, eyes, or vagina.

What is DUOBRII® Lotion?

DUOBRII (halobetasol propionate and tazarotene) Lotion, 0.01%/0.045%, is a prescription medicine used on the skin (topical) to treat adults with plaque psoriasis. It is not known if DUOBRII Lotion is safe and effective in children.

Important Safety Information

  • DUOBRII Lotion is for use on the skin only; do not use it in your mouth, eyes, or vagina.
What is the most important Information I should know about DUOBRII Lotion?

DUOBRII Lotion may cause birth defects if used during pregnancy.

A negative pregnancy test must be obtained before females of child-bearing age start using DUOBRII Lotion and they must use effective birth control during treatment. Begin treatment during a normal menstrual period.

Stop using DUOBRII Lotion and tell your healthcare provider right away if you become pregnant while using DUOBRII Lotion.

Before you use DUOBRII Lotion, tell your healthcare provider if you:

  • have eczema or any other skin problems, including skin infections, which may need to be treated before using DUOBRII.
  • have diabetes, adrenal gland problems or liver problems.
  • are breastfeeding or plan to breastfeed. If you use DUOBRII and breastfeed, do not apply DUOBRII to your nipple area.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

  • Especially tell your healthcare provider if you take corticosteroids by mouth or injection or use other skin products that contain corticosteroids.
  • Ask your healthcare provider for a list of medicines that may make your skin more sensitive to sunlight.
What should I avoid during treatment with DUOBRII?
  • To avoid a severe sunburn, avoid sunlight, including sunlamps and tanning beds, as much as possible, and use sunscreen, protective clothing and a hat while in sunlight. Talk to your healthcare provider if you get sunburn, and do not use DUOBRII Lotion until your sunburn is healed.
  • Avoid using DUOBRII on skin with eczema because it may cause severe irritation.
DUOBRII may cause side effects, including:
  • If too much DUOBRII passes through your skin it can cause adrenal glands to stop working
  • Cushing’s syndrome, a condition from too much exposure to the hormone cortisol
  • High blood sugar (hyperglycemia)
  • Effects of growth and weight in children
  • Skin irritation. If you get too much skin irritation at the site of application, your healthcare provider may tell you to interrupt or stop using DUOBRII or to use it less often.
  • Vision problems, including an increased chance of developing cataracts and glaucoma. Tell your healthcare provider about any vision problems during treatment.

The most common side effects of DUOBRII Lotion include: redness, itching, swelling, burning, stinging, application site pain, inflamed hair follicles (folliculitis), thinning of the skin (atrophy), peeling and rash.

To report SUSPECTED ADVERSE REACTIONS, contact Ortho Dermatologics at 1-800-321-4576 or FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.

Please click here for full Prescribing Information, including Patient Information.

*This offer does not apply to any state or federal government insurance program. Additional restrictions may apply. For more details go to OrthoRxAccess.com.