Two well-known ingredients. One unique lotion.

DUOBRII Lotion combines two well-known ingredients into a single, first-of-its-kind topical treatment.
The strong antiinflammatory agent (halobetasol propionate) works to clear plaques,
while the vitamin A derivative (tazarotene) helps extend the clearing process.

‘Hal’the Corticosteroid(halobetasol propionate)
‘Taz’the Retinoid(tazarotene)
‘Hal’the Corticosteroid(halobetasol propionate)

Hal provides powerful antiinflammatory abilities and reduces the burning and irritation associated with vitamin A derivatives.

Across two clinical trials, the most common adverse events that patients experienced with DUOBRII Lotion were skin irritation (7%), application site pain (3%), skin thinning (2%), and excoriation (2%).

 
‘Taz’the Retinoid(tazarotene)

Taz has been shown to reduce skin thinning associated with corticosteroids and extend the clearing process even after treatment, with well-established tolerability in psoriasis when partnered with a corticosteroid.

Across two clinical trials, 2% of patients using DUOBRII Lotion experienced skin thinning.

Newly diagnosed? Learn more about plaque psoriasis

DUOBRII Lotion extends the clearing process: 12 weeks of results with 8 weeks of treatment

  • 8 Weeks
    Over 40% of patients had “clear“ or “almost clear“ skin at 8 weeks across 2 clinical trials*
  • 2%
    With DUOBRII Lotion, only 2% of patients experienced skin thinning The most common side effects that patients experienced with DUOBRII Lotion were skin irritation (7%), application site pain (3%), skin thinning (2%), and excoriation (2%)
  • 1 Month
    Continued clearance 1 month after DUOBRII Lotion Across both trials, 33% of patients still had “clear“ or “almost clear“ skin 4 weeks post treatment*

*Clear = no evidence of scaling, redness, or plaque elevation above normal skin level.
Almost clear = some plaques with fine scales, faint pink/light redness on most plaques, slight or barely noticeable elevation of plaques above normal skin level.

Now you can keep on going

Unlike other steroids that have time limits on use, you can keep on using DUOBRII Lotion as needed. Discontinue use once your skin becomes clear. Talk to your healthcare provider if you experience skin thinning, stretch marks, spider veins or inflamed hair follicles.

Long lasting. Once your skin is clear, it can stay that way for up to 3 months after you stop using DUOBRII Lotion.

A once-daily lotion that:

  • Hydrates the skin
    and moisturizes
    for up to 24 hours
  • Doesn’t leave
    a greasy residue
  • Goes on easily
    and feels light on
    the skin
 

DUOBRII Lotion can fit into your daily routine
once a day

  • 1
    Apply a thin layer to the affected area
  • 2
    Rub in gently

NOTE : If you have to be in the sun, always use sunscreen and wear protective clothing over treated areas. Avoid exposure to sunlamps while using DUOBRII Lotion.
Visit the FAQ section for other important information regarding DUOBRII Lotion.

What is DUOBRII™ Lotion?

Important Safety Information

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DUOBRII (halobetasol propionate and tazarotene) Lotion, 0.01%/0.045%, is a prescription medicine used on the skin (topical) to treat people with plaque psoriasis. It is not known if DUOBRII Lotion is safe and effective in children.

Important Safety Information

  • DUOBRII Lotion is for use on the skin only; do not use it in your mouth, eyes, or vagina.
  • DUOBRII Lotion is for use on the skin only; do not use it in your mouth, eyes, or vagina.

What is DUOBRII™ Lotion?

DUOBRII (halobetasol propionate and tazarotene) Lotion, 0.01%/0.045%, is a prescription medicine used on the skin (topical) to treat adults with plaque psoriasis. It is not known if DUOBRII Lotion is safe and effective in children.

Important Safety Information

  • DUOBRII Lotion is for use on the skin only; do not use it in your mouth, eyes, or vagina.
What is the most important Information I should know about DUOBRII Lotion?

DUOBRII Lotion may cause birth defects if used during pregnancy.

A negative pregnancy test must be obtained before females of child-bearing age start using DUOBRII Lotion and they must use effective birth control during treatment. Begin treatment during a normal menstrual period.

Stop using DUOBRII Lotion and tell your healthcare provider right away if you become pregnant while using DUOBRII Lotion.

Before you use DUOBRII Lotion, tell your healthcare provider if you:

  • have eczema or any other skin problems, including skin infections, which may need to be treated before using DUOBRII.
  • have diabetes, adrenal gland problems or liver problems.
  • are breastfeeding or plan to breastfeed. If you use DUOBRII and breastfeed, do not apply DUOBRII to your nipple area.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

  • Especially tell your healthcare provider if you take corticosteroids by mouth or injection or use other skin products that contain corticosteroids.
  • Ask your healthcare provider for a list of medicines that may make your skin more sensitive to sunlight.
What should I avoid during treatment with DUOBRII?
  • To avoid a severe sunburn, avoid sunlight, including sunlamps and tanning beds, as much as possible, and use sunscreen, protective clothing and a hat while in sunlight. Talk to your healthcare provider if you get sunburn, and do not use DUOBRII Lotion until your sunburn is healed.
  • Avoid using DUOBRII on skin with eczema because it may cause severe irritation.
DUOBRII may cause side effects, including:
  • If too much DUOBRII passes through your skin it can cause adrenal glands to stop working
  • Cushing’s syndrome, a condition from too much exposure to the hormone cortisol
  • High blood sugar (hyperglycemia)
  • Effects of growth and weight in children
  • Skin irritation. If you get too much skin irritation at the site of application, your healthcare provider may tell you to interrupt or stop using DUOBRII or to use it less often.
  • Vision problems, including an increased chance of developing cataracts and glaucoma. Tell your healthcare provider about any vision problems during treatment.

The most common side effects of DUOBRII Lotion include: redness, itching, swelling, burning, stinging, application site pain, inflamed hair follicles (folliculitis), thinning of the skin (atrophy), peeling and rash.

To report SUSPECTED ADVERSE REACTIONS, contact Ortho Dermatologics at 1-800-321-4576 or FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.

Please click here for full Prescribing Information, including Patient Information.