A: DUOBRII Lotion is a prescription medicine made up of a combination of halobetasol propionate and tazarotene that is used on the skin to treat plaque psoriasis in adults. Do not use DUOBRII Lotion in your mouth, eyes or vagina.

A: You must not be pregnant when you start using DUOBRII Lotion or become pregnant during treatment with DUOBRII Lotion. DUOBRII Lotion may cause birth defects if used during pregnancy.

For females who are able to get pregnant:

• Your doctor should order a pregnancy test for you within 2 weeks before you begin treatment with DUOBRII Lotion to be sure that you are not pregnant.
• Begin treatment with DUOBRII Lotion during a normal menstrual period.
• Use an effective form of birth control during treatment with DUOBRII Lotion. Talk with your doctor about birth control options to prevent pregnancy during treatment with DUOBRII Lotion.
• Stop using DUOBRII Lotion and tell your doctor right away if you become pregnant while using DUOBRII Lotion.

A: The active ingredients in DUOBRII Lotion can pass through your skin. If too much halobetasol passes through your skin from using DUOBRII Lotion, it can cause adrenal glands to stop working. During treatment with DUOBRII Lotion, your doctor will monitor you for symptoms of your adrenal glands being unable to make enough cortisol, a hormone that is important to several body systems.

A: Before you use DUOBRII Lotion, tell your doctor if you:

• have eczema or any other skin problems.
• have a skin infection. You may need medicine to treat the skin infection before using DUOBRII.
• have diabetes.
• have adrenal gland problems.
• have liver problems.
• are breastfeeding or plan to breastfeed. It is not known if DUOBRII passes into your breast milk. If you use DUOBRII and breastfeed, do not apply DUOBRII to your nipple or areola to avoid getting DUOBRII into your baby’s mouth.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you take corticosteroids by mouth or injection, or use other products on your skin that contain corticosteroids.

Certain medicines may make your skin more sensitive to sunlight. Ask your healthcare provider for a list of these medicines if you are not sure.

DUOBRII Lotion cannot be used during pregnancy (see question above about use during pregnancy).

A: Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements, and cosmetics. Especially tell your doctor if you take corticosteroids by mouth, or injection, or use other products on your skin that contain corticosteroids. Certain medicines may make your skin more sensitive to sunlight. Ask your doctor for a list of these medicines if you are not sure.

A: Avoid sunlight, including sunlamps and tanning beds, during your treatment with DUOBRII Lotion. DUOBRII Lotion can make your skin more sensitive to the sun and the light from sunlamps and tanning beds. You could get severe sunburn. Use sunscreen, and wear a hat and clothes that cover your skin if you have to be in sunlight.

• Talk to your doctor if you get sunburn during treatment with DUOBRII. If you do get sunburn, do not use DUOBRII until your sunburn is healed.

Avoid using DUOBRII on skin with eczema because it may cause severe irritation.

A: DUOBRII may cause side effects, including:

• See “What is the most important information I should know about DUOBRII Lotion?”
• DUOBRII Lotion can pass through your skin. Too much DUOBRII Lotion passing through your skin can cause adrenal glands to stop working.
• Cushing’s syndrome, a condition that happens when your body is exposed to too much of the hormone cortisol.
• High blood sugar (hyperglycemia).
• Effects of growth and weight in children.
• Skin irritation. DUOBRII may cause increased skin irritation. Tell your doctor if you develop any skin irritation during your treatment with DUOBRII. If you develop skin irritation, your doctor may tell you to interrupt or stop using DUOBRII, or tell you to use DUOBRII less often.
• Sensitivity to light and risk of sunburn. See “What should I avoid during treatment with DUOBRII Lotion?”
• Vision problems. DUOBRII may increase your chance of developing cataract(s) and glaucoma. Tell your doctor if you have blurred vision or other vision problems during your treatment with DUOBRII.

The most common side effects of DUOBRII Lotion include: redness, itching, swelling, burning, stinging, application site pain, inflamed hair follicles (folliculitis), thinning of the skin (atrophy), peeling and rash.

These are not all of the possible side effects of DUOBRII.

A: DUOBRII Lotion is a combination product containing halobetasol propionate and tazarotene as the active ingredients in a white to off-white lotion formulation.

A: The inactive ingredients in DUOBRII Lotion are carbomer copolymer type B, carbomer homopolymer type A, diethyl sebacate, edetate disodium dihydrate, light mineral oil, methylparaben, propylparaben, purified water, sodium hydroxide, sorbitan monooleate and sorbitol solution, 70%.

A: There are many medications available to treat psoriasis. Talk to your doctor about which medications are right for you.

A: You should use DUOBRII Lotion exactly as your doctor has instructed you to. If your doctor tells you to use it on your scalp, use it exactly as your doctor instructed.

A: DUOBRII Lotion is for use on the skin only; do not use it in your mouth, eyes, or vagina. DUOBRII Lotion also should not be used on the face, groin, or in the armpit. Do not apply it to skin that has eczema.

A: You may use a cream or lotion to soften or moisten your skin as often as desired, except within an hour of applying DUOBRII Lotion. However, make sure to tell your doctor about any cosmetics you use, including moisturizers, creams, lotions, or products that can dry out your skin.