Savings Offer

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Exclusively at Walgreens and other participating independent pharmacies

Most eligible commercially insured  
patients pay as little as a:

$25 Co-Pay*

Ortho Dermatologics Rx Access Program offers DUOBRII Lotion savings

For eligible patients whose commercial insurance does not cover DUOBRII Lotion, patients will pay as little as a $65 co-pay. This offer is available on up to 6 refills of your prescription.

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Ortho Dermatologics Rx Access Program offers DUOBRII Lotion savings

*This offer is not valid for any person eligible for reimbursement of prescriptions, in whole or in part, by any federal, state, or other governmental programs, including, but not limited to, Medicare (including Medicare Advantage and Part A, B, and D plans), Medicaid, TRICARE, Veterans Administration or Department of Defense health coverage, CHAMPUS, the Puerto Rico Government Health Insurance Plan, or any other federal or state healthcare programs. This offer is good only in the U.S. at retail pharmacies owned and operated by Walgreen Co. (or its affiliates) or other participating independent retail pharmacies. This offer is not valid where otherwise prohibited, taxed or otherwise restricted. Click here for full Eligibility Terms and Conditions.

Insured not covered is defined as a patient who has commercial insurance but the drug is not covered on the plan’s formulary or has an NDC block, prior authorization, step edit or other restriction that has not been met.

Downloadable Resources

How to use DUOBRII Lotion

Detailed instructions and tips are available in this helpful guide to using DUOBRII Lotion.

Guide to using DUOBRII Lotion

Discussing your psoriasis
with your doctor

Ensure you get the best treatment by knowing the right questions to ask your doctor. Use this Doctor Discussion Guide to get started.

Doctor discussion guide for plaque psoriasis

Frequently Asked Questions

Q. What is DUOBRII Lotion?

A: DUOBRII Lotion is a prescription medicine made up of a combination of halobetasol propionate and tazarotene that is used on the skin to treat plaque psoriasis in adults. Do not use DUOBRII Lotion in your mouth, eyes or vagina.

Q. Can I use DUOBRII Lotion if I’m pregnant or breastfeeding?

A: You must not be pregnant when you start using DUOBRII Lotion or become pregnant during treatment with DUOBRII Lotion. DUOBRII Lotion may cause birth defects if used during pregnancy.

For females who are able to get pregnant:

  • Your doctor should order a pregnancy test for you within 2 weeks before you begin treatment with DUOBRII Lotion to be sure that you are not pregnant.
  • Begin treatment with DUOBRII Lotion during a normal menstrual period.
  • Use an effective form of birth control during treatment with DUOBRII Lotion. Talk with your doctor about birth control options to prevent pregnancy during treatment with DUOBRII Lotion.
  • Stop using DUOBRII Lotion and tell your doctor right away if you become pregnant while using DUOBRII Lotion.
Q. How long can I use DUOBRII Lotion?

A: Unlike using other potent-to-superpotent steroids alone, there is no limit to how long you can use DUOBRII Lotion (once a day) as long as you stop using it when your skin becomes clear. Stop using when your skin becomes clear or if you experience side effects.

Once clear, you may stay that way for up to 3 months after using DUOBRII Lotion.

Q. Who else should not use DUOBRII Lotion?

A: Do not use DUOBRII Lotion on skin where you have eczema because it may cause severe irritation.

If you have a sunburn, do not use DUOBRII Lotion until fully recovered.

If you have considerable sun exposure due to your occupation or are sensitive to sunlight, exercise particular caution when using DUOBRII Lotion.

Q. What other safety information do I need to know?

A: DUOBRII Lotion may cause HPA axis suppression, which is when your body is unable to make enough cortisol, a hormone that is important to several body systems. Your doctor will monitor you for symptoms during treatment with DUOBRII Lotion.

Q. What should I tell my doctor before using DUOBRII Lotion?

A: Before you use DUOBRII Lotion, tell your doctor if you:

  • have eczema or any other skin problems.
  • have a skin infection. You may need medicine to treat the skin infection before using DUOBRII.
  • have diabetes.
  • have adrenal gland problems.
  • have liver problems.
  • are breastfeeding or plan to breastfeed. It is not known if DUOBRII passes into your breast milk. If you use DUOBRII and breastfeed, do not apply DUOBRII to your nipple or areola to avoid getting DUOBRII into your baby’s mouth.

DUOBRII Lotion cannot be used during pregnancy (see question above about use during pregnancy).

Q. Can I use DUOBRII Lotion if I’m taking other medications for psoriasis?

A: Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements, and cosmetics. Especially tell your doctor if you take corticosteroids by mouth, or injection, or use other products on your skin that contain corticosteroids. Certain medicines may make your skin more sensitive to sunlight. Ask your doctor for a list of these medicines if you are not sure.

Q. What should I avoid while using DUOBRII Lotion?

A: Avoid sunlight, including sunlamps and tanning beds, during your treatment with DUOBRII Lotion. DUOBRII Lotion can make your skin more sensitive to the sun and the light from sunlamps and tanning beds. You could get severe sunburn. Use sunscreen, and wear a hat and clothes that cover your skin if you have to be in sunlight.

  • Talk to your doctor if you get sunburn during treatment with DUOBRII. If you do get sunburn, do not use DUOBRII until your sunburn is healed.

Avoid using DUOBRII on skin with eczema because it may cause severe irritation.

Q. What are the possible side effects of DUOBRII Lotion?

A: DUOBRII may cause side effects, including:

  • See “What is the most important information I should know about DUOBRII Lotion?”
  • DUOBRII Lotion can pass through your skin. Too much DUOBRII Lotion passing through your skin can cause adrenal glands to stop working.
  • Cushing’s syndrome, a condition that happens when your body is exposed to too much of the hormone cortisol.
  • High blood sugar (hyperglycemia).
  • Effects of growth and weight in children.
  • Skin irritation. DUOBRII may cause increased skin irritation. Tell your doctor if you develop any skin irritation during your treatment with DUOBRII. If you develop skin irritation, your doctor may tell you to interrupt or stop using DUOBRII, or tell you to use DUOBRII less often.
  • Sensitivity to light and risk of sunburn. See “What should I avoid during treatment with DUOBRII Lotion?”
  • Vision problems. DUOBRII may increase your chance of developing cataract(s) and glaucoma. Tell your doctor if you have blurred vision or other vision problems during your treatment with DUOBRII.

The most common side effects of DUOBRII Lotion include: redness, itching, swelling, burning, stinging, application site pain, inflamed hair follicles (folliculitis), thinning of the skin (atrophy), peeling and rash.

These are not all of the possible side effects of DUOBRII.

Q. What are the active ingredients in DUOBRII Lotion?

A: DUOBRII Lotion is a combination product containing halobetasol propionate and tazarotene as the active ingredients in a white to off-white lotion formulation.

Q. What other ingredients are in DUOBRII Lotion?

A: Other ingredients in DUOBRII Lotion are carbomer copolymer type B, carbomer homopolymer type A, diethyl sebacate, edetate disodium dihydrate, light mineral oil, methylparaben, propylparaben, purified water, sodium hydroxide, sorbitan monooleate and sorbitol solution, 70%.

Q. Can I just use an over-the-counter lotion?

A: There are many medications available to treat psoriasis. Talk to your doctor about which medications are right for you.

Q. Where on my body can I not use DUOBRII Lotion?

A: DUOBRII Lotion is for use on the skin only; do not use it in your mouth, eyes, or vagina. DUOBRII Lotion also should not be used on the face, groin, or in the armpit. Do not apply it to skin that has eczema.

Q. Can I use a moisturizer while using DUOBRII Lotion?

A: You may use a cream or lotion to soften or moisten your skin as often as desired, except within an hour of applying DUOBRII Lotion. However, make sure to tell your doctor about any cosmetics you use, including moisturizers, creams, lotions, or products that can dry out your skin.

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